Role of Remifentanil on MAC, Bcl-2, and Bax Levels in Traumatic Brain Injury Rat Models
نویسندگان
چکیده
Abstract: Introduction: Traumatic Brain Injury (TBI) conditions require immediate treatment such as the administration of analgesics and sedation, including remifentanil. TBI will affect levels several inflammatory apoptotic proteins MAC, Bax, Bcl-2. Remifentanil with its high affinity to μ-receptors is thought these has neuroprotective properties prevent secondary brain injury. Objectives: This research aims determine effect giving remifentanil on Bcl-2, Bax in rats traumatic Materials Methods: Experimental was conducted 24 male Wistar rats, which were randomly divided into four groups. The Group-1 (G1) received an intravenous injection NaCl, Group-2 (G2) given normal saline after induction using modified Feeney method. Furthermore, Group-3 Group-4 (G3 G4) fentanyl or induction. rat tissue analyzed for ELISA data statistically by ANOVA test, followed Post-Hoc Multiple Comparison Test (p<0.05). Results: MAC reduced subjects, but increased Bcl-2 levels. Post Hoc comparisons showed a significant difference between all group pairs Meanwhile, more optimal results than those fentanyl. Conclusion: can act neuroprotector model decreasing increasing Keywords: Remifentanil,
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Education and Research
سال: 2023
ISSN: ['0019-5464']
DOI: https://doi.org/10.5530/ijper.57.2s.37